Journal article

Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin.

Caroline Messer, Raymond Boston, Derek Leroith, Eliza Geer, Joshua D Miller, Marcelo Messer, Walter Futterweit

Endocr Pract | Published : 2012

Abstract

OBJECTIVE: To determine whether the administration of 6 months of daily metformin treatment in women with polycystic ovary syndrome (PCOS) would significantly improve pancreatic β-cell function as measured by an increase in the disposition index. METHODS: We enrolled women with PCOS from a private practice and from the Mount Sinai Hospital Endocrinology Clinic. All patients underwent frequently sampled intravenous glucose tolerance tests both on and off 500 to 1000 mg of twice daily metformin. Values of insulin sensitivity, glucose effectiveness, acute insulin response to glucose, and disposition index were calculated for each test. The product of acute insulin response to glucose and insuli..

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University of Melbourne Researchers