Comparison of cortisol and ACTH responses after administration of thyrotropin releasing hormone in normal horses and those with pituitary pars intermedia dysfunction.
J Beech, R Boston, S Lindborg
J Vet Intern Med | Published : 2011
BACKGROUND: Changes in both adrenocorticotropin (ACTH) and cortisol concentration in response to thyrotropin releasing hormone (TRH) administration have been used to diagnose equine pituitary pars intermedia dysfunction (PPID), but the use of the 2 hormones has not been compared. HYPOTHESES: Measuring ACTH concentration is superior to measuring cortisol concentration after TRH administration in differentiating between normal horses and those with PPID, and the 2 hormone concentrations are disassociated in PPID horses. ANIMALS: Eleven horses and 2 ponies with PPID and 19 normal horses. METHODS: A study evaluating cortisol and ACTH concentrations before and at 14, 30, and 60 minutes after TRH ..View full abstract