Journal article

Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging.

Grigorios Korosoglou, Robert G Weiss, Dorota A Kedziorek, Piotr Walczak, Wesley D Gilson, Michael Schär, David E Sosnovik, Dara L Kraitchman, Raymond C Boston, Jeff WM Bulte, Ralph Weissleder, Matthias Stuber

J Am Coll Cardiol | Published : 2008


OBJECTIVES: This study was designed to identify macrophage-rich atherosclerotic plaque noninvasively by imaging the tissue uptake of long-circulating superparamagnetic nanoparticles with a positive contrast off-resonance imaging sequence (inversion recovery with ON-resonant water suppression [IRON]). BACKGROUND: The sudden rupture of macrophage-rich atherosclerotic plaques can trigger the formation of an occlusive thrombus in coronary vessels, resulting in acute myocardial infarction. Therefore, a noninvasive technique that can identify macrophage-rich plaques and thereby assist with risk stratification of patients with atherosclerosis would be of great potential clinical utility. METHODS: E..

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University of Melbourne Researchers