Journal article

Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase.

Anne E Sumner, Gloria L Vega, David J Genovese, Karl B Finley, Richard N Bergman, Raymond C Boston

Metabolism | Published : 2005


Abstract Lipoprotein lipase (LPL), the enzyme responsible for hydrolyzing triglyceride (TG) in plasma lipoproteins, is a key regulator of plasma TG levels. In Caucasians, postheparin-LPL (PH-LPL) activity is impaired in the presence of insulin resistance and leads to elevated TG levels. However, African Americans are often both insulin-resistant and normotriglyceridemic. But in African Americans, the effect of insulin resistance on PH-LPL activity has not been studied. In African Americans, if insulin resistance is not associated with a decrease in PH-LPL activity, this could account for the simultaneous presence of insulin resistance and normotriglyceridemia. Therefore, our goal was to dete..

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University of Melbourne Researchers