Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies.
Grigorios Korosoglou, Saurabh Shah, Evert-Jan Vonken, Wesley D Gilson, Michael Schär, Lijun Tang, Dara L Kraitchman, Raymond C Boston, David E Sosnovik, Robert G Weiss, Ralph Weissleder, Matthias Stuber
Radiology | Published : 2008
PURPOSE: To evaluate the utility of inversion recovery with on-resonant water suppression (IRON) in combination with injection of the long-circulating monocrystalline iron oxide nanoparticle (MION)-47 for contrast material-enhanced magnetic resonance (MR) angiography. MATERIALS AND METHODS: Experiments were approved by the institutional animal care committee. Eleven rabbits were imaged at baseline before injection of a contrast agent and then serially 5-30 minutes, 2 hours, 1 day, and 3 days after a single intravenous bolus injection of 80 micromol of MION-47 per kilogram of body weight (n = 6) or 250 micromol/kg MION-47 (n = 5). Conventional T1-weighted MR angiography and IRON MR angiograph..View full abstract