Journal article

Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.

John S Millar, Cyrille Maugeais, Katsunori Ikewaki, Daniel M Kolansky, P Hugh R Barrett, Elaine C Budreck, Raymond C Boston, Norio Tada, Seibu Mochizuki, Joep C Defesche, James M Wilson, Daniel J Rader

Arterioscler Thromb Vasc Biol | Published : 2005

Abstract

OBJECTIVE: We addressed the role of the low-density lipoprotein (LDL) receptor in determining clearance rates and production rate (PR) of apolipoprotein B (apoB) in humans. METHODS AND RESULTS: Kinetic studies using endogenous labeling of apoB with deuterated leucine were performed in 7 genetically defined patients with homozygous familial hypercholesterolemia (FH) and compared with 4 controls. The fractional catabolic rates (FCR) and PRs for apoB were determined by multicompartmental modeling. The FCRs of very-low-density lipoprotein 1 (VLDL1), VLDL2, intermediate-density lipoprotein (IDL), and LDL apoB were lower in FH than in controls, with the LDL apoB FCR being significantly lower (0.14..

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University of Melbourne Researchers