[Study on optimization of formulation of Danggui Liuhuang effervescent granules].
Ping Zheng, Li-Juan Meng, Guo-Ping Sun, Wen-Zhong Wang
Zhong Yao Cai | Published : 2011
OBJECTIVE: To optimize the formulation of Danggui Liuhuang effervescent granules. METHODS: By means of quadratic regression rotation-orthogonal combination design, the effect of the proper proportion between citric acid and sodium bicarbonate, as well as the proper quantity of polyethylene glycol 6000 and sodium cyclamate on the dissolubility and pH of effervescent granules was studied. RESULTS: The best formulation was as follows: citric acid: sodium bicarbonate = 0.75: 1, the percentage of polyethylene glycol 6000 and cyclamate was 3.25% and 0.89%, respectively. CONCLUSION: The dissolubility and pH of the effervescent granules are better and the taste is satisfactory.