[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
Ping Zheng, Wen-zhong Wang, Peng Zhang, Jian Han, Li-zhi Wu
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Published : 2006
OBJECTIVE: To optimize preparative technique for banxia-houpu effervescent tablets. METHODS: Based on the pH, disintegration time limited, taste, and rigidity of effervescent tablets, the proper proportion between citric acid and sodium bicarbonate, as well as the proper quantity of polyethylene glycol 6000 and sodium cyclamate in the effervescent tablets were determined by using orthogonal design. The content of magnolol and honokiol in effervescent tablets were measured by HPLC. RESULTS: The optimal preparative technique was: cirtic acid: sodium bicarbonate = 0.65:1. The percentage of polyethylene glycol 6000 was 85%, and the percentage of sodium cyclamate was 1.0%. CONCLUSION: The prepara..View full abstract