Journal article
Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants
D Ryan, MR Sutherland, TJ Flores, AL Kent, JE Dahlstrom, VG Puelles, JF Bertram, AP McMahon, MH Little, L Moore, MJ Black
Ebiomedicine | ELSEVIER SCIENCE BV | Published : 2018
Abstract
Background: During normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority of nephrons formed late in gestation. The aim of this study was to morphologically examine nephrogenesis in fetal human kidneys from 20 to 41 weeks of gestation. Methods: Kidney samples were obtained at autopsy from 71 infants that died acutely in utero or within 24 h after birth. Using image analysis, nephrogenic zone width, the number of glomerular generations, renal corpuscle cross-sectional area and the cellular composition of glomeruli were examined. Kidneys from female and male infants were analysed separately. Findings: The number of glomerular gen..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported by funding from the National Health and Medical Research Council (NHMRC) (1011136) of Australia and National Institutes of Health (NIH) USA grant 3U01DK094526-04S1 (PI A P McMahon). Author Danica Ryan was the recipient of the Biomedicine Discovery Scholarship from Monash University and author Megan R. Sutherland was supported by a NHMRC CJ Martin Fellowship. Funders had no role in the study design, data collection, data analysis, interpretation, or writing of the report.