Effect of Renal Denervation on Blood Pressure and MicroRNA 181a in Hypertensive Schlager Mice

Abstract

Hypertensive Schlager mice (BPH) are hypertensive due to an exaggerated contribution of the sympathetic nervous system (SNS) and renin angiotensin system (RAS). The latter was associated with reduced expression of the renin regulatory micro RNA 181a. We therefore determined the effect of bilateral renal denervation (Rx) on blood pressure (BP) in BPH compared to normotensive BPN. BP was measured by radiotelemetry and Rx performed by surgery and 10% phenol. After 3 weeks, BP was 8±2 mmHg lower than sham in Rx BPH mice but Rx had no effect in BPN. Following Rx, enalapril (RAS contribution) decreased BP more in BPH mice compared to sham group but had no effect in BPN. The depressor response to p..