Journal article
CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies
D Wolf, F Jehle, AO Rodriguez, B Dufner, N Hoppe, C Colberg, A Lozhkin, N Bassler, B Rupprecht, A Wiedemann, I Hilgendorf, P Stachon, F Willecke, M Febbraio, CJ Binder, C Bode, A Zirlik, K Peter
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Background: Adipose tissue inflammation fuels the metabolic syndrome. We recently reported that CD40L - an established marker and mediator of cardiovascular disease - induces inflammatory cytokine production in adipose cells in vitro. Here, we tested the hypothesis that CD40L deficiency modulates adipose tissue inflammation in vivo. Methodology/Principal Findings: WT or CD40L -/- mice consumed a high fat diet (HFD) for 20 weeks. Inflammatory cell recruitment was impaired in mice lacking CD40L as shown by a decrease of adipose tissue macrophages, B-cells, and an increase in protective T-regulatory cells. Mechanistically, CD40L-deficient mice expressed significantly lower levels of the pro-inf..
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Awarded by Deutsche Forschungsgemeinschaft (DFG)
Funding Acknowledgements
This work was supported by research grants from the Deutsche Forschungsgemeinschaft (DFG ZI743/3-1 and 3-2) and from the Fritz-Thyssen-Stiftung to AZ and grants from the National Health and Medical Research Council of Australia to KP. KP is a Future Fellow of the Australian Research Council. DW was funded by a fellowship of the Bayer Science and Education Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.