Journal article

CALBINDIN-D-28K LIKE IMMUNOREACTIVITY IN SUPERFICIAL DORSAL HORN NEURONS AND EFFECTS OF SCIATIC CHRONIC CONSTRICTION INJURY

MJ Stebbing, S Balasubramanyan, PA Smith

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

Abstract

The neuropathic pain that results from peripheral nerve injury is associated with alterations in the properties of neurons in the superficial spinal laminae. Chronic constriction injury (CCI) of the rat sciatic nerve increases excitatory synaptic drive to excitatory neurons in the substantia gelatinosa while limiting that to inhibitory neurons. Since the calcium-binding protein calbindin D-28K has been associated with excitatory neurons, we examined whether CCI altered the properties of neurons expressing calbindin-like immunoreactivity (Cal+). These account for 30% of the neurons in lamina I and II. Calbindin did not co-localize with any particular electrophysiological phenotype of neuron; ..

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University of Melbourne Researchers