Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?
James E Biggs, Van B Lu, Martin J Stebbing, Sridhar Balasubramanyan, Peter A Smith
Molecular Pain | SAGE PUBLICATIONS INC | Published : 2010
Peripheral nerve injury activates spinal microglia. This leads to enduring changes in the properties of dorsal horn neurons that initiate central sensitization and the onset of neuropathic pain. Although a variety of neuropeptides, cytokines, chemokines and neurotransmitters have been implicated at various points in this process, it is possible that much of the information transfer between activated microglia and neurons, at least in this context, may be explicable in terms of the actions of brain derived neurotrophic factor (BDNF). Microglial-derived BDNF mediates central sensitization in lamina I by attenuating inhibitory synaptic transmission. This involves an alteration in the chloride e..View full abstract
Awarded by Canadian Institutes of Health Research (CIHR)
We thank Aaron Lai for carrying out ELISA measurements of BDNF concentrations in organotypic cultures and JihuanYin for art work in Figure 1. Supported by the Canadian Institutes of Health Research (CIHR; Funding reference # 81089). VBL received studentship awards from CIHR and from the Alberta Heritage Foundation for Medical Research (AHFMR).