Illuminating the covert mission of mononuclear phagocytes in their regional niches
Shu Zhen Chong, Maximilien Evrard, Chi Ching Goh, Lai Guan Ng
CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2018
Monocytes, dendritic cells (DCs) and macrophages have been classically categorized into the mononuclear phagocyte system (MPS) based on their similar functional and phenotypic characteristics. While an increasing amount of research has revealed substantial ontogenic and functional differences among these cells, the reasons behind their heterogeneity and strategic positioning in specific niches throughout the body are yet to be fully elucidated. In this review, we outline how recent advances in intravital imaging studies have dissected this phenomenon and have allowed us to appreciate how MPS cells exploit their regional niches to specialize and maximize their functional properties. Understan..View full abstract
We regret that owing to space limitations, we could only describe a selection of papers and therefore have not been able to cite all relevant literature. This work was supported by the Singapore Immunology Network (SIgN) core funding.