T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion
Daniel T Utzschneider, Amandine Legat, Silvia A Fuertes Marraco, Lucie Carrie, Immanuel Luescher, Daniel E Speiser, Dietmar Zehn
Nature Immunology | NATURE PUBLISHING GROUP | Published : 2013
Awarded by Swiss National Science Foundation
We thank S. Enouz, S. Oberle and M. Prlic for discussions and critical review of the manuscript; A. Oxenius (Institute of Microbiology, Swiss Federal Institute of Technology Zurich) for P14 alpha beta mice; P. Fink (University of Washington, Seattle) for V<INF>beta</INF>5 mice; and A. Wilson and H.R. MacDonald (Ludwig Center for Cancer Research, University of Lausanne) for antibodies specific to CD45.2 (clone 104) and CD45.1 (clone A20). Supported by the Swiss Vaccine Research Institute (D.Z.) and the Swiss National Science Foundation (CRSII3_141879 to D.Z. and D.E.S.).