Journal article
MicroRNA-155 is required for effector cd8 t cell responses to virus infection and cancer
JC Dudda, B Salaun, Y Ji, DC Palmer, GC Monnot, E Merck, C Boudousquie, DT Utzschneider, TM Escobar, R Perret, SA Muljo, M Hebeisen, N Rufer, D Zehn, A Donda, NP Restifo, W Held, L Gattinoni, P Romero
Immunity | CELL PRESS | Published : 2013
Abstract
MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8+ T cell immunity remains unknown. Here we report that miRNA-155 is required for CD8+ T cell responses to both virus and cancer. In the absence of miRNA-155, accumulation of effector CD8+ T cells was severely reduced during acute and chronic viral infections and control of virus replication was impaired. Similarly, Mir155-/- CD8+ T cells were ineffective at controlling tumor growth, whereas miRNA-155 overexpression enhanced the antitumor response. miRNA-155 deficiency resulted in accumulation of suppressor of cytokine signaling-1 (SOCS-1) causing defective cytokine signaling through STAT5. Consis..
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Awarded by Foundation for Research, Science and Technology
Funding Acknowledgements
We thank D. Labes for technical assistance and I. Luescher for providing tetramers. We also thank P. Martiat and B. Badran for critical input. J. C. D. and B. S. were supported in part by a grant from the MEDIC Foundation, R. P. by New Zealand Foundation for Research, Science and Technology, W. H. and C. B. by the Swiss National Science Foundation (SNSF). G. C. M., D. Z., and P. R. were supported in part by a Prodoc and a Sinergia grants from the SNSF. Y. J., D. C. P., N. P. R. and L. G. were supported by the Intramural Research Programs of the US NIH National Cancer Institute, Center for Cancer Research. T. M. E. and S. A. M. were supported by the Intramural Research Program of the NIH National Institute of Allergy and Infectious Diseases.