Journal article
Cognitive training in Parkinson disease: A systematic review and meta-analysis
IHK Leung, CC Walton, H Hallock, SJG Lewis, M Valenzuela, A Lampit
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
Open access
Abstract
Objective: To quantify the effects of cognitive training (CT) on cognitive and behavioral outcome measures in patients with Parkinson disease (PD). Methods: We systematically searched 5 databases for randomized controlled trials (RCTs) of CT in patients with PD reporting cognitive or behavioral outcomes. Efficacy was measured as standardized mean difference (Hedges g) of post-training change. Results: Seven studies encompassing 272 patients with Hoehn & Yahr Stages 1-3 were included. The overall effect of CT over and above control conditions was small but statistically significant (7 studies: g 0.23, 95% confidence interval [CI] 0.014-0.44, p 0.037). True heterogeneity across studies was low..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
C.C.W. is supported by an Australian Postgraduate Award at the University of Sydney. S.J.G.L. is supported by a National Health and Medical Research Council of Australia (NHMRC) Practitioner Fellowship (ID 1003007). M.V. is an NHMRC Clinical Career Development Research Fellow (ID 1004156). A.L. is supported by an NHMRC Project Grant (ID 1084880).