Journal article
Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise
C Suo, MF Singh, N Gates, W Wen, P Sachdev, H Brodaty, N Saigal, GC Wilson, J Meiklejohn, N Singh, BT Baune, M Baker, N Foroughi, Y Wang, Y Mavros, A Lampit, I Leung, MJ Valenzuela
Molecular Psychiatry | SPRINGERNATURE | Published : 2016
DOI: 10.1038/mp.2016.19
Abstract
Physical and cognitive exercise may prevent or delay dementia in later life but the neural mechanisms underlying these therapeutic benefits are largely unknown. We examined structural and functional magnetic resonance imaging (MRI) brain changes after 6 months of progressive resistance training (PRT), computerized cognitive training (CCT) or combined intervention. A total of 100 older individuals (68 females, average age=70.1, s.d.±6.7, 55-87 years) with dementia prodrome mild cognitive impairment were recruited in the SMART (Study of Mental Activity and Resistance Training) Trial. Participants were randomly assigned into four intervention groups: PRT+CCT, PRT+SHAM CCT, CCT+SHAM PRT and doub..
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Awarded by National Science Foundation
Funding Acknowledgements
This study was funded by the National Health and Medical Research Council (NHMRC) of Australia Dementia Research Grant, Project Grant ID No. 512672 from 2008 to 2011. Additional funding for a research assistant position was sourced from the NHMRC Program Grant ID No. 568969 and the project was supported by the University of Sydney and University of New South Wales. MJV was supported by the University of New South Wales Vice Chancellor's Fellowship and a NHMRC Clinical Career Development Fellowship (1004156) and the Sydney Medical School Foundation. YM, GCW and JM are supported by the CRN for Advancing Exercise and Sport Science as a postdoctoral research associate, PhD scholarship and as a research assistant respectively. This work fulfilled a portion of the degree requirements for PhD for Nicola Gates and Chao Suo. We also thank Brooke McMahon for assistance with recruitment and training, Dominique Williamson, Dr Shelley Kay and Dr Angela Wright for assistance with assessments, Brad Lloyd and Dr Angela Wright for their assistance with Manual of Procedures preparation, Kate Bradshaw for her assistance with recruitment and Diana Marcela Martinez Piamba for hippocampal tracing. Donations for participant rewards were received from Gregory and Carr Funerals. We also thank the extraordinary generosity and commitment of the participants and their families who devoted their time to this project.