Journal article
Immune checkpoint blockade in infectious diseases
MN Wykes, SR Lewin
Nature Reviews Immunology | NATURE PORTFOLIO | Published : 2018
DOI: 10.1038/nri.2017.112
Abstract
The upregulation of immune checkpoint molecules, such as programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute infections, such as malaria, as well as during chronic persistent viral infections, including HIV and hepatitis B virus. These pathways are important for preventing immune-driven pathology but can also limit immune-mediated clearance of the infection. The recent success of immune checkpoint blockade in cancer therapy suggests that targeting these pathways would also be effective for preventing and treating a range of infectious diseases. Here, we review our current understanding of immune checkpoint pathways in the pa..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The authors sincerely thank M. Flynn for the design and implementation of the figures. The authors acknowledge editorial assistance of S. Johnatty from SugarApple Communications in finalizing the manuscript. The authors thank N. Chomont, University of Montreal, for helpful comments and discussion. The authors acknowledge the support of The National Health and Medical Research Council (NHMRC) (Australia). S. R. L. is an NHMRC practitioner fellow and is supported by the National Institutes for Health Delaney AIDS Research Enterprise (DARE U19 AI126611 and AI096109) and the American Foundation for AIDS Research.