Journal article
An International, Multicenter, Observational Study of Cerebral Oxygenation during Infant and Neonatal Anesthesia
VA Olbrecht, J Skowno, V Marchesini, L Ding, Y Jiang, CG Ward, G Yu, H Liu, B Schurink, L Vutskits, JC De Graaff, FX McGowan, BS Von Ungern-Sternberg, CD Kurth, A Davidson
Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Abstract
Background: General anesthesia during infancy is associated with neurocognitive abnormalities. Potential mechanisms include anesthetic neurotoxicity, surgical disease, and cerebral hypoxia-ischemia. This study aimed to determine the incidence of low cerebral oxygenation and associated factors during general anesthesia in infants. Methods: This multicenter study enrolled 453 infants aged less than 6 months having general anesthesia for 30 min or more. Regional cerebral oxygenation was measured by near-infrared spectroscopy. We defined events (more than 3 min) for low cerebral oxygenation as mild (60 to 69% or 11 to 20% below baseline), moderate (50 to 59% or 21 to 30% below baseline), or seve..
View full abstractGrants
Awarded by Princess Margaret Hospital Foundation
Funding Acknowledgements
Supported by Australian and New Zealand College of Anaesthetists Project Grant 15/021 (West End, Queensland, Australia) and Society of Pediatric Anaesthetists of New Zealand and Australia Research Grant 2016 (Morrisett, New South Wales, Australia), as well as the Princess Margaret Hospital Foundation (to Dr. von Ungern-Sternberg; Perth, Western Australia, Australia), the Callahan Estate (to Dr. von Ungern-Sternberg; Perth, Western Australia, Australia), and the Stan Perron Fellowship (to Dr. von Ungern-Sternberg; Perth, Western Australia, Australia).