Journal article

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chanchal Chandramouli, Melissa E Reichelt, Claire L Curl, Upasna Varma, Laura A Bienvenu, Parisa Koutsifeli, Antonia JA Raaijmakers, Miles J De Blasio, Cheng Xue Qin, Alicia J Jenkins, Rebecca H Ritchie, Kimberley M Mellor, Lea MD Delbridge

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018

Abstract

Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascular risk associated with diabetes is more marked for women, but an understanding of the role of diastolic dysfunction in female susceptibility to diabetic cardiomyopathy is lacking. To investigate the sex-specific relationship between systemic diabetic status and in vivo occurrence of diastolic dysfunction, diabetes was induced in male and female mice by streptozotocin (5x daily i.p. 55 mg/kg). Echocardiography was performed at 7 weeks post-diabetes induction, cardiac collagen content assessed by picrosirius red staining, and gene expression measured using qPCR. The..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC Peter Doherty Fellowship


Awarded by NHMRC Senior Research Fellowship


Funding Acknowledgements

The technical expertise from the Biomedical Histology Facility, and assistance in tissue collection from Gabriel Bernasochi, Brendan Ma, and Johannes Janssens is acknowledged. This work was supported by a National Health and Medical Research Council of Australia (NHMRC) project grant (APP1027865) and the Diabetes Australia Research Trust. MER is the recipient of an NHMRC Peter Doherty Fellowship (GNT0628841) and RHR is the recipient of an NHMRC Senior Research Fellowship (ID1059960).