Journal article

Visual recovery as the target for glaucoma

V Chrysostomou, RJ Hatch, T Colgan, JP Paul, P van Wijngaarden, I Trounce, MIG Lopez Sanchez, K Bell, F Grus, JG Crowston

OPHTHALMOLOGE | SPRINGER HEIDELBERG | Published : 2019

Abstract

BACKGROUND: Visual recovery is an established but poorly studied phenomenon in glaucoma. OBJECTIVE: To provide insights into functional recovery of retinal ganglion cells (RGCs) with a view to providing information on the development of forms of treatment that improve RGC function after injury. METHOD: A model of recoverable RGC function in the mouse eye, induced by short-term elevation of intraocular pressure (IOP). RESULTS: The RGCs manifest near complete functional recovery after a prolonged period of dysfunction following acute IOP elevation. Increasing age and a high fat diet were subsequently found to impair recovery, whereas exercise substantially improved recovery such that older mic..

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