Journal article
The regulation of lymphocyte activation and proliferation
S Heinzel, JM Marchingo, MB Horton, PD Hodgkin
Current Opinion in Immunology | CURRENT BIOLOGY LTD | Published : 2018
Abstract
Activation induced proliferation and clonal expansion of antigen specific lymphocytes is a hallmark of the adaptive immune response to pathogens. Recent studies identify two distinct control phases. In the first T and B lymphocytes integrate antigen and additional costimuli to motivate a programmed proliferative burst that ceases with a return to cell quiescence and eventual death. This proliferative burst is autonomously timed, ensuring an appropriate response magnitude whilst preventing uncontrolled expansion. This initial response is subject to further modification and extension by a range of signals that modify, expand and direct the emergence of a rich array of new cell types. Thus, bot..
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Awarded by H2020 Marie Skłodowska-Curie Actions
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia via Project Grant 1010654, Program Grant 1054925 and a fellowship to P.D.H. as well as an Australian Government National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme Grant 361646. J.M.M. was supported by a European Molecular Biology Organisation long-term fellowship (ALTF 1543-2015, including support from Marie Curie Action LTFCOFUND2013, GA-2013-609409) and has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Action Individual Fellowship Grant Agreement No. 705984.