The androgen receptor in bone marrow progenitor cells negatively regulates fat mass
Patricia K Russell, Salvatore Mangiafico, Barbara C Fam, Michele V Clarke, Evelyn S Marin, Sofianos Andrikopoulos, Kristine M Wiren, Jeffrey D Zajac, Rachel A Davey
JOURNAL OF ENDOCRINOLOGY | BIOSCIENTIFICA LTD | Published : 2018
It is well established that testosterone negatively regulates fat mass in humans and mice; however, the mechanism by which testosterone exerts these effects is poorly understood. We and others have shown that deletion of the androgen receptor (AR) in male mice results in a phenotype that mimics the three key clinical aspects of hypogonadism in human males; increased fat mass and decreased bone and muscle mass. We now show that replacement of the Ar gene specifically in mesenchymal progenitor cells (PCs) residing in the bone marrow of Global-ARKO mice, in the absence of the AR in all other tissues (PC-AR Gene Replacements), completely attenuates their increased fat accumulation. Inguinal subc..View full abstract
Awarded by National Health and Medical Research Council of Australia
The work was supported by the National Health and Medical Research Council of Australia (Project Grant 566503), The University of Melbourne Grant Support Scheme, The Sir Edward Dunlop Medical Research Foundation, The Austin Health Research Foundation and a Les and Eva Erdi Research Grant.