Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes
David S Williams, Dmitri Mouradov, Robert N Jorissen, Marsali R Newman, Elham Amini, David K Nickless, Julie A Teague, Catherine G Fang, Michelle Palmieri, Marie J Parsons, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Ian Faragher, Ian T Jones, Peter Gibbs, Oliver M Sieber
GUT | BMJ PUBLISHING GROUP | Published : 2019
OBJECTIVE: Tumour-infiltrating lymphocyte (TIL) response and deficient DNA mismatch repair (dMMR) are determinants of prognosis in colorectal cancer. Although highly correlated, evidence suggests that these are independent predictors of outcome. However, the prognostic significance of combined TIL/MMR classification and how this compares to the major genomic and transcriptomic subtypes remain unclear. DESIGN: A prospective cohort of 1265 patients with stage II/III cancer was examined for TIL/MMR status and BRAF/KRAS mutations. Consensus molecular subtype (CMS) status was determined for 142 cases. Associations with 5-year disease-free survival (DFS) were evaluated and validated in an independ..View full abstract
Awarded by Cancer Australia
Awarded by Cancer Council Victoria
Awarded by NHMRC
This work was supported by a Cancer Australia Project Grant (APP1120882), a Cancer Council Victoria Grant-in-Aid (1060964), the Victorian Government's Operational Infrastructure Support Program, a University of Melbourne Department of Pathology Career Development Award and an Austin Medical Research Foundation Project Grant. OMS is a NHMRC RD. Wright Biomedical Fellow (APP1062226). MP is supported by a Cancer Therapeutics CRC (CTx) Top Up PhD Scholarship and Australian Government Research Training Program Scholarship.