Journal article
Neonatal BCG vaccination influences cytokine responses to toll-like receptor ligands and heterologous antigens
B Freyne, S Donath, S Germano, K Gardiner, D Casalaz, RM Robins-Browne, N Amenyogbe, NL Messina, MG Netea, KL Flanagan, T Kollmann, N Curtis
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2018
Abstract
Background. BCG vaccination is associated with a reduction in all-cause infant mortality in high-mortality settings. The underlying mechanisms remain uncertain, but long-term modulation of the innate immune response (trained immunity) may be involved. Methods. Whole-blood specimens, collected 7 days after randomization from 212 neonates enrolled in a randomized trial of neonatal BCG vaccination, were stimulated with killed pathogens and Toll-like receptor (TLR) ligands to interrogate cytokine responses. Results. BCG-vaccinated infants had increased production of interleukin 6 (IL-6) in unstimulated samples and decreased production of interleukin 1 receptor antagonist, IL-6, and IL-10 and the..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (NHMRC) (grants GNT1051228 and GNT1099680), Murdoch Children's Research Institute (Infection and Immunity Theme Grant), the University of Melbourne (Human Rights Scholarship to B. F.), the European Society of Paediatric Infectious Diseases (ESPID) (fellowship to B. F.), the European Research Council (ERC) (Consolidator Grant 310372 to M. G. N.), and the Netherlands Organization for Scientific Research (Spinoza Grant to M. G. N.).