Journal article
A common brain network among state, trait, and pathological anxiety from whole-brain functional connectivity
Y Takagi, Y Sakai, Y Abe, S Nishida, BJ Harrison, I Martínez-Zalacaín, C Soriano-Mas, J Narumoto, SC Tanaka
Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018
Abstract
Anxiety is one of the most common mental states of humans. Although it drives us to avoid frightening situations and to achieve our goals, it may also impose significant suffering and burden if it becomes extreme. Because we experience anxiety in a variety of forms, previous studies investigated neural substrates of anxiety in a variety of ways. These studies revealed that individuals with high state, trait, or pathological anxiety showed altered neural substrates. However, no studies have directly investigated whether the different dimensions of anxiety share a common neural substrate, despite its theoretical and practical importance. Here, we investigated a brain network of anxiety shared ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was conducted as the "Application of DecNef for development of diagnostic and cure system for mental disorders and construction of clinical application bases" of the Strategic Research Program for Brain Sciences from the Japan Agency for Medical Research and Development, AMED. This work was partly supported by JSPS KAKENHI Grant Number 25119001, the Joint Usage/Research Center at ISER, Osaka University, and a grant from the Carlos III Health Institute (PI13/01958). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CPII16/00048). Data were provided [in part] by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. We thank O. Yamashita, H. Imamizu, B. Seymour and W. Yoshida for helpful discussions and proofreading the manuscript. We thank T. Okada, H. Ito, and the technical engineers for their assistance in MRI data acquisition. We thank K. Tamura, S. Kimura, and K. Inoue for their assistance in the assessment of patients. We thank N. Izumihara for his support for visualization.