Journal article
High performance plasma amyloid-β biomarkers for Alzheimer's disease
A Nakamura, N Kaneko, VL Villemagne, T Kato, J Doecke, V Doré, C Fowler, QX Li, R Martins, C Rowe, T Tomita, K Matsuzaki, K Ishii, K Ishii, Y Arahata, S Iwamoto, K Ito, K Tanaka, CL Masters, K Yanagisawa
Nature | Published : 2018
DOI: 10.1038/nature25456
Abstract
To facilitate clinical trials of disease-modifying therapies for Alzheimer's disease, which are expected to be most efficacious at the earliest and mildest stages of the disease, supportive biomarker information is necessary. The only validated methods for identifying amyloid-β deposition in the brain - the earliest pathological signature of Alzheimer's disease - are amyloid-β positron-emission tomography (PET) imaging or measurement of amyloid-β in cerebrospinal fluid. Therefore, a minimally invasive, cost-effective blood-based biomarker is desirable. Despite much effort, to our knowledge, no study has validated the clinical utility of blood-based amyloid-β markers. Here we demonstrate the ..
View full abstractGrants
Awarded by Alzheimer's Association
Funding Acknowledgements
The NCGG study group thank all participants of the study, clinicians who referred patients, and all the staff who supported the MULNIAD project. We thank N. Sugimoto for conducting statistical analyses, S. Niida and the NCGG Biobank members for the management of plasma samples and M. Kawakage for data monitoring. This study was supported by The Research Funding for Longevity Sciences (25-24 and 26-30) from the National Center for Geriatrics and Gerontology, and partially supported by Research and Development Grants for Dementia from the Japan Agency for Medical Research and Development, AMED. This study is registered under UMIN ID: 000016144. The AIBL study would like to thank all participants of the study and the clinicians who referred participants. The AIBL study (https://aibl.csiro.au/) is a consortium between Austin Health, CSIRO, Edith Cowan University and the Florey Institute, The University of Melbourne. Partial financial support was provided by the Alzheimer's Association (US), the Alzheimer's Drug Discovery Foundation, an anonymous foundation, the Cooperative Research Centre for Mental Health, CSIRO Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government Operational Infrastructure Support program, the McCusker Alzheimer's Research Foundation, the National Health and Medical Research Council, and the Yulgilbar Foundation. Funding sources had no role in study design, data collection, data analyses or data interpretation.