Electrical receptive fields of retinal ganglion cells: Influence of presynaptic neurons

Matias I Maturana; Nicholas V Apollo; David J Garrett; Tatiana Kameneva; Shaun L Cloherty; David B Grayden; Anthony N Burkitt; Michael R Ibbotson; Hamish Meffin

Journal article

Electrical receptive fields of retinal ganglion cells: Influence of presynaptic neurons

Matias I Maturana, Nicholas V Apollo, David J Garrett, Tatiana Kameneva, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Michael R Ibbotson, Hamish Meffin

PLOS COMPUTATIONAL BIOLOGY | PUBLIC LIBRARY SCIENCE | Published : 2018

DOI: 10.1371/journal.pcbi.1005997

Download PDF

Abstract

Implantable retinal stimulators activate surviving neurons to restore a sense of vision in people who have lost their photoreceptors through degenerative diseases. Complex spatial and temporal interactions occur in the retina during multi-electrode stimulation. Due to these complexities, most existing implants activate only a few electrodes at a time, limiting the repertoire of available stimulation patterns. Measuring the spatiotemporal interactions between electrodes and retinal cells, and incorporating them into a model may lead to improved stimulation algorithms that exploit the interactions. Here, we present a computational model that accurately predicts both the spatial and temporal no..

View full abstract

University of Melbourne Researchers

Matias Maturana Author Medicine - St Vincent's Hospital

Hamish Meffin Author Biomedical Engineering

David Grayden Author Biomedical Engineering

David Garrett Author Physics

Related Projects (5)

NEXT GENERATION CYBERNETICS: LONG TERM CARBON FIBRE DUAL STIMULATION / RECORDING ELECTRODE ARRAYS FOR CLOSED LOOP NEURAL IMPLANTS

Electrodes implanted in the brain have enormous potential for treating a range of conditions from epilepsy to control of prosthetics for pat..

ARC CENTRE OF EXCELLENCE FOR INTEGRATIVE BRAIN FUNCTION

Neural Activity Shaping for Retinal and Cochlear Implants

This project aims to develop methods to control and optimise the spatial patterns of neural activity evoked by neural prostheses in order to..

NEXT GENERATION CYBERNETICS: LONG TERM CARBON FIBRE DUAL STIMULATION / RECORDING ELECTRODE ARRAYS FOR CLOSED LOOP NEURAL IMPLANTS

Electrodes implanted in the brain have enormous potential for treating a range of conditions from epilepsy to control of prosthetics for pat..

NEURO-FEEDBACK FOR IMPROVED EFFICACY OF RETINAL PROSTHESES

Bionic eyes offer the possibility to return sight to the blind. Existing retinal implants are effective at delivering basic visual percepts,..

Grants

Awarded by Australian Research Council, Centre of Excellence for Integrative Brain Function

Awarded by Australian Research Council Discovery Projects funding scheme

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council, Project Grant (https://www.nhmrc.gov.au/). HM and MRI acknowledge supported through the Australian Research Council, Centre of Excellence for Integrative Brain Function (CE140100007, http://www.arc.gov.au/arc-centre-excellence-integrative-brain-function). ANB and TK acknowledge support through the Australian Research Council Discovery Projects funding scheme (DP140104533; http://www.arc.gov.au/). DJG and NVP are supported by National Health and Medical Research Council grant (GNT1101717, https://www.nhmrc.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.