Journal article
Electrical receptive fields of retinal ganglion cells: Influence of presynaptic neurons
Matias I Maturana, Nicholas V Apollo, David J Garrett, Tatiana Kameneva, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Michael R Ibbotson, Hamish Meffin
PLOS COMPUTATIONAL BIOLOGY | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
Implantable retinal stimulators activate surviving neurons to restore a sense of vision in people who have lost their photoreceptors through degenerative diseases. Complex spatial and temporal interactions occur in the retina during multi-electrode stimulation. Due to these complexities, most existing implants activate only a few electrodes at a time, limiting the repertoire of available stimulation patterns. Measuring the spatiotemporal interactions between electrodes and retinal cells, and incorporating them into a model may lead to improved stimulation algorithms that exploit the interactions. Here, we present a computational model that accurately predicts both the spatial and temporal no..
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Grants
Awarded by Australian Research Council, Centre of Excellence for Integrative Brain Function
Awarded by Australian Research Council Discovery Projects funding scheme
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by the National Health and Medical Research Council, Project Grant (https://www.nhmrc.gov.au/). HM and MRI acknowledge supported through the Australian Research Council, Centre of Excellence for Integrative Brain Function (CE140100007, http://www.arc.gov.au/arc-centre-excellence-integrative-brain-function). ANB and TK acknowledge support through the Australian Research Council Discovery Projects funding scheme (DP140104533; http://www.arc.gov.au/). DJG and NVP are supported by National Health and Medical Research Council grant (GNT1101717, https://www.nhmrc.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.