Serum Methylarginines and Hearing Loss in a Population-based Cohort of Older Adults
Mark McEvoy, David C Harris, Arduino A Mangoni, Julia Z Sarant
OTOLOGY & NEUROTOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
OBJECTIVE: Age-related hearing loss is associated with endothelial dysfunction and increased cardiovascular risk, suggesting a vascular etiology. Methylarginines are endogenous nitric oxide synthase inhibitors that cause endothelial dysfunction and increase cardiovascular disease risk. This study is the first to examine the hypothesis that higher serum concentrations of methylarginines are associated with greater hearing loss prevalence. STUDY DESIGN/PATIENTS: Cross-sectional audiometric data on hearing levels, and serum methylarginines were collected from a population-based sample of 630 older community-dwelling adults. RESULTS: Linear regression analysis showed a statistically significant ..View full abstract
This research was conducted as part of the Hunter Community Study, funded by the University of Newcastle and the Extending Treatments, Education and Networks study, funded by the Hunter Medical Research Institute and Xstrata Coal.