Journal article
Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium
K Aldape, SB Amin, DM Ashley, JS Barnholtz-Sloan, AJ Bates, R Beroukhim, C Bock, DJ Brat, EB Claus, JF Costello, JF de Groot, G Finocchiaro, PJ French, HK Gan, B Griffith, CC Herold-Mende, C Horbinski, A Iavarone, SN Kalkanis, K Karabatsou Show all
Neuro Oncology | OXFORD UNIV PRESS INC | Published : 2018
Abstract
Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GL..
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Awarded by Winship Cancer Institute
Funding Acknowledgements
The GLASS Consortium is indebted to support from the National Brain Tumor Society, Oligo Research Fund, and Alan and Ashley Dabbiere (R.G.W.V., J.C.). GLASS-AT is supported in part by an Austrian Science Fund grant KLI394 (A.W.),the Austrian Academy of Science (C.B.), and the European Research Council (European Union Horizon 2020 Research and Innovation Program, Grant Agreement 679146) (C.B.). GLASS-L is supported by a Televie grant (S.P.N.). GLASS-NL receives funding from the Dutch Cancer Society KWF Grant 11026 (P.W.). GLASS-USA has been supported by the Cancer Prevention and Research Institute of Texas Grant R140606 (R.G.W.V., J.H., J.D.G.). Tissue procurement at the Winship Cancer Institute is supported by NIH-NCI P30-CA138292 (E.G.V.M.). Support is also provided by a Henry Ford Hospital institutional grant; Grant 2015/07925-5, 2016/15485-8, 2014/08321-3 from the Sao Paulo Research Foundation (FAPESP) (H.N., C.F.S.); and the Leeds Teaching Hospitals Charitable Foundation Grant 9R11/14-11 (L.F.S.). The Else Kroner-Fresenius-Stiftung (2015_Kolleg_14) supports the clinical and tissue database at the University of Tubingen (G.T.). Support for GLASS-AU is provided by with NHMRC Program Grant 1037786 to the NHMRC Clinical Trials Centre, and Cancer Australia Support for COGNO (M.K.).