Journal article

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Rebecca Stephens, Krystle Lim, Marta Portela, Marc Kvansakul, Patrick O Humbert, Helena E Richardson

JOURNAL OF MOLECULAR BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018

Abstract

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The Scribble module proteins play key functions in the establishment and maintenance of different modes of cell polarity, as well as in the control of tissue growth, differentiation and directed cell migration, and therefore are major regulators of tissue development and homeostasis. Whilst molecular details are known regarding the roles of Scribble module proteins in cell polarity regulation, their precise mode of action in the regulation of other key cellular processes remains enigmatic. An accumulating body of evi..

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Grants

Awarded by National Health and Medical Research Council Australia (NHMRC)


Awarded by NHMRC Fellowship


Awarded by Australian Research Council Fellowship


Awarded by Juan de la Cierva-Incorporacion postdoctoral fellowship from the Spanish Ministerio de Ciencia e Innovacion (MICINN)


Funding Acknowledgements

This work was supported by an National Health and Medical Research Council Australia (NHMRC) Project Grant (APP1103871) to MK, POH and HER, an NHMRC Fellowship (APP1020056) to PH, an Australian Research Council Fellowship (FT130101349) to MK, a Juan de la Cierva-Incorporacion postdoctoral fellowship (IJCI-2014-19272) from the Spanish Ministerio de Ciencia e Innovacion (MICINN) to MP, a Australian Government RTP Scholarship to RS, and funds from La Trobe University and the La Trobe Institute of Molecular Science to HER.