Journal article
Efficacy and tolerability of adjuvant lacosamide: The role of clinical characteristics and mechanisms of action of concomitant AEDs
A Neal, W D'Souza, G Hepworth, N Lawn, M Cook, A Nikpour
Epilepsy and Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018
Abstract
Objective: The objective of this study was to analyze the effectiveness and long-term tolerability of adjuvant lacosamide (LCM) in a multicenter cohort. We aim to assess outcomes of LCM-containing antiepileptic drug (AED) combinations based upon ‘mechanism of action’ (MoA) and patient's clinical features. Methods: Consecutive patients commenced on LCM, with focal epilepsy were identified from three Australian hospitals. The 12-month efficacy endpoints were greater than 50% reduction in seizure frequency (responders) and seizure freedom. Tolerability endpoints were cessation of LCM for any reason, cessation due to side-effects and censoring due to inefficacy. Outcomes were assessed according ..
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Awarded by UCB
Funding Acknowledgements
This work was supported by an investigator-initiated grant from UCB (AD MED 008/2015.12.01). UCB was not involved in the study design, the collection, analysis and interpretation of the data gathered, the writing of the report, or the decision to submit the article for publication. Dr. Andrew Neal has previously received the Epilepsy Society Australia UCB Clinical Pharma Scholarship. Nicholas Lawn has received honoraria and research support from UCB. None of the other authors have any conflicts of interest to disclose.