Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin
Amelia J Brennan, Ruby HP Law, Paul J Conroy, Tahereh Noori, Natalya Lukoyanova, Helen Saibil, Hideo Yagita, Annette Ciccone, Sandra Verschoor, James C Whisstock, Joseph A Trapani, Ilia Voskoboinik
Cell Death & Differentiation | NATURE PUBLISHING GROUP | Published : 2018
Awarded by Wellcome Trust
This work was supported by project and programme grants from the National Health and Medical Research Council of Australia (to IV, JCW and JAT), and Wellcome Trust equipment grant 079605 to HS. IV and JCW are supported by a National Health and Medical Research Council of Australia Fellowships. We thank Colin House and Conor Kearney for critical reading of the manuscript, and Mr Samuel J Redmond for his technical assistance.