Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials.
undefined Colorectal Cancer Collaborative Group
The Lancet | Published : 2001
BACKGROUND: At least 28 randomised, controlled trials have compared outcomes of surgery for rectal cancer combined with preoperative or postoperative radiotherapy with those of surgery alone. We have done a collaborative meta-analysis of these results to give a more balanced view of the total evidence and to increase statistical precision. METHODS: We centrally checked and analysed individual patient data from 22 randomised comparisons between preoperative (6,350 patients in 14 trials) or postoperative (2157 in eight trials) radiotherapy and no radiotherapy for rectal cancer. FINDINGS: Overall survival was only marginally better in patients who were allocated to radiotherapy than in those al..View full abstract