Journal article

Innate immune responses following Kawasaki disease and toxic shock syndrome

Katherine YH Chen, Nicole Messina, Susie Germano, Rhian Bonnici, Bridget Freyne, Michael Cheung, Greta Goldsmith, Tobias R Kollmann, Michael Levin, David Burgner, Nigel Curtis

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018

Abstract

The pathogenesis of Kawasaki disease (KD) remains unknown and there is accumulating evidence for the importance of the innate immune system in initiating and mediating the host inflammatory response. We compared innate immune responses in KD and toxic shock syndrome (TSS) participants more than two years after their acute illness with control participants to investigate differences in their immune phenotype. Toxic shock syndrome shares many clinical features with KD; by including both disease groups we endeavoured to explore changes in innate immune responses following acute inflammatory illnesses more broadly. We measured the in vitro production of interferon (IFN)-γ, tumour necrosis factor..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC) Senior Research Fellowship


Awarded by National Heart Foundation Future Leader Fellowship


Awarded by NHMRC


Awarded by Royal Children's Hospital Foundation


Funding Acknowledgements

KYHC holds an Australian Government Research Training Program scholarship from The University of Melbourne and a Postgraduate Health Research Scholarship from Murdoch Children's Research Institute. DB holds a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1064629) and an honorary National Heart Foundation Future Leader Fellowship (100369). NC is an investigator on NHMRC project grant 1064408. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group is supported by The RCH1000, The Royal Children's Hospital Foundation and Big W. The authors also wish to thank Jam and Jelly Foundation for their financial support for this research. These entities had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; or decision to submit the manuscript for publication.