Journal article

Four days of simulated shift work reduces insulin sensitivity in humans

R Bescos, MJ Boden, ML Jackson, AJ Trewin, EC Marin, I Levinger, A Garnham, DS Hiam, F Falcao-Tebas, F Conte, JA Owens, DJ Kennaway, GK McConell

ACTA PHYSIOLOGICA | WILEY | Published : 2018


AIM: The aim of this study was to investigate the effects of 4 consecutive simulated night shifts on glucose homeostasis, mitochondrial function and central and peripheral rhythmicities compared with a simulated day shift schedule. METHODS: Seventeen healthy adults (8M:9F) matched for sleep, physical activity and dietary/fat intake participated in this study (night shift work n = 9; day shift work n = 8). Glucose tolerance and insulin sensitivity before and after 4 nights of shift work were measured by an intravenous glucose tolerance test and a hyperinsulinaemic euglycaemic clamp respectively. Muscles biopsies were obtained to determine insulin signalling and mitochondrial function. Central..

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University of Melbourne Researchers