Cerebrospinal Fluid Biomarkers are Differentially Related to Structural and Functional Changes in Dementia of the Alzheimer's Type

CB Malpas; MM Saling; D Velakoulis; P Desmond; RJ Hicks; H Zetterberg; K Blennow; TJ O'Brien

Journal article

Cerebrospinal Fluid Biomarkers are Differentially Related to Structural and Functional Changes in Dementia of the Alzheimer's Type

CB Malpas, MM Saling, D Velakoulis, P Desmond, RJ Hicks, H Zetterberg, K Blennow, TJ O'Brien

Journal of Alzheimer S Disease | IOS PRESS | Published : 2018

DOI: 10.3233/JAD-170250

Abstract

The two cardinal pathologies of Alzheimer's disease (AD) develop according to distinct anatomical trajectories. Cerebral tau-related pathology first accumulates in the mesial temporal region, while amyloid-related pathology first appears in neocortex. The eventual distributions of these pathologies reflect their anatomical origins. An implication is that the cardinal pathologies might exert preferential effects on the structurofunctional brain changes observed in AD. We investigated this hypothesis in 39 patients with dementia of the Alzheimer's type. Interrelationships were analyzed between cerebrospinal fluid biomarkers of the cardinal pathologies, volumetric brain changes using magnetic r..

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University of Melbourne Researchers

Charles Malpas Author

Michael Saling Author

Dennis Velakoulis Author

Grants

Funding Acknowledgements

Charles B. Malpas was supported by an Alzheimer's Australia Research Foundation Viertel postgraduate research scholarship during his doctoral candidature. He is currently supported by a National Health and Medical Research Council (NHMRC) Peter Doherty Australian Biomedical Fellowship.