Neurological effects of iron supplementation in infancy: finding the balance between health and harm in iron-replete infants
Dominic J Hare, Barbara Rita Cardoso, Ewa A Szymlek-Gay, Beverley-Ann Biggs
The Lancet Child & Adolescent Health | ELSEVIER SCI LTD | Published : 2018
Iron mediates many biochemical processes in neural networks that proliferate during brain development. Insufficient iron causes irreversible neurodevelopmental deficits, and most high-income countries recommend that infants older than 4-6 months receive additional iron via food fortification or supplementation to prevent iron-deficiency anaemia. Now that the prevalence of iron-deficiency anaemia in children has decreased to less than 10% in most developed countries, concerns that the recommended intakes far exceed those required to prevent iron-deficiency anaemia have been raised, and emerging evidence suggests that iron overexposure could be linked to adverse outcomes later in life. In this..View full abstract
The Florey Institute acknowledges the Victorian Government's Operational Infrastructure Support Program.