HIV and HCV therapies in 2016: Optimal regimens

Abstract

Approximately 30% of HIV individuals are coinfected with HCV. It is known that HIV accelerates liver fibrosis progression, even with the use of combination antiretroviral therapy, and HCV is now a leading cause of morbidity and mortality in this patient population. Past HCV therapy with pegylated interferon and ribavirin in this setting has demonstrated poor outcomes, which were inferior to those seen in HCV-monoinfected populations, especially in patients with genotype 1 infections. This and the high rate of adverse events with these agents resulted in very limited uptake of these treatment options. The recent advent of direct-acting antiviral therapy for HCV has resulted in vastly improved..