Journal article

Persistent infections in immunocompromised hosts are rarely sources of new pathogen variants

John-Sebastian Eden, Rebecca H Chisholm, Rowena A Bull, Peter A White, Edward C Holmes, Mark M Tanaka

Virus Evolution | OXFORD UNIV PRESS | Published : 2017

Abstract

Many viruses, including human norovirus and influenza, cause self-limiting diseases of short duration. However, infection by the same viruses in an immunocompromised host can result in prolonged illness in the absence of effective treatment. Such persistent infections are often characterized by increased genetic diversity with potentially elevated rates of evolution compared to acute infections, leading to suggestions that immunocompromised hosts represent an important reservoir for the emergence of novel viral variants. Here, we develop a mathematical model that combines epidemiological dynamics with within-host evolution to quantify the relative contribution of immunocompromised hosts to t..

View full abstract

Grants

Awarded by Australian NHMRC with an Early Career Fellowship


Awarded by NHMRC Australia Fellowship


Awarded by Australian Research Council


Funding Acknowledgements

J.S.E. is supported through the Australian NHMRC with an Early Career Fellowship (1073466). E.C.H. is funded by an NHMRC Australia Fellowship (GNT1037231). M.M.T. is supported by an Australian Research Council grant (FT140100398).