Persistent infections in immunocompromised hosts are rarely sources of new pathogen variants
John-Sebastian Eden, Rebecca H Chisholm, Rowena A Bull, Peter A White, Edward C Holmes, Mark M Tanaka
Virus Evolution | OXFORD UNIV PRESS | Published : 2017
Many viruses, including human norovirus and influenza, cause self-limiting diseases of short duration. However, infection by the same viruses in an immunocompromised host can result in prolonged illness in the absence of effective treatment. Such persistent infections are often characterized by increased genetic diversity with potentially elevated rates of evolution compared to acute infections, leading to suggestions that immunocompromised hosts represent an important reservoir for the emergence of novel viral variants. Here, we develop a mathematical model that combines epidemiological dynamics with within-host evolution to quantify the relative contribution of immunocompromised hosts to t..View full abstract
Awarded by Australian NHMRC with an Early Career Fellowship
Awarded by NHMRC Australia Fellowship
Awarded by Australian Research Council
J.S.E. is supported through the Australian NHMRC with an Early Career Fellowship (1073466). E.C.H. is funded by an NHMRC Australia Fellowship (GNT1037231). M.M.T. is supported by an Australian Research Council grant (FT140100398).