Journal article

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Puya Gharahkhani, Kathryn P Burdon, Jessica N Cooke Bailey, Alex W Hewitt, Matthew H Law, Louis R Pasquale, Jae H Kang, Jonathan L Haines, Emmanuelle Souzeau, Tiger Zhou, Owen M Siggs, John Landers, Mona Awadalla, Shiwani Sharma, Richard A Mills, Bronwyn Ridge, David Lynn, Robert Casson, Stuart L Graham, Ivan Goldberg Show all

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2018


Awarded by National Institutes of Health (NIH) Center for Inherited Research (CIDR) as part of an NIH/National Eye Institute (NEI)

Awarded by NCATS/NIH grant

Awarded by National Heart, Lung, and Blood Institute

Awarded by National Health and Medical Research Council of Australia

Awarded by NIH/NEI

Awarded by National Cancer Institute

Awarded by National Eye Institute

Awarded by GENEVA project

Awarded by US National Cancer Institute

Awarded by National Eye Institute through ARRA grants

Awarded by NIH grants

Awarded by NHMRC

Awarded by National Health and Medical Research Council (NHMRC) of Australia



Funding Acknowledgements

ANZRAG: Support for recruitment of ANZRAG was provided by the Royal Australian and New Zealand College of Ophthalmology (RANZCO) Eye Foundation. Genotyping was funded by the National Health and Medical Research Council of Australia (#535074 and #1023911). This work was also supported by funding from NHMRC #1031362 awarded to J.E.C., NHMRC #1037838 awarded to A.W.H., NHMRC #1048037 awarded to S.L.G., NHMRC #1009844 awarded to R.J.C. and I.G., NHMRC #1031920 and Alcon Research Institute grant awarded to D.A.M., Allergan Unrestricted grant awarded to A.J.W., and the BrightFocus Foundation and a Ramaciotti Establishment Grant. The authors acknowledge the support of Ms Bronwyn Usher-Ridge in patient recruitment and data collection, and Dr Patrick Danoy and Dr Johanna Hadler for genotyping. Controls for the ANZRAG cohort were drawn from the Australian Cancer Study, the Study of Digestive Health, a study of inflammatory bowel diseases, a study of endometriosis, and QIMR Berghofer twin study. The Australian Cancer Study was supported by the Queensland Cancer Fund and the National Health and Medical Research Council (NHMRC) of Australia (Program no. 199600, awarded to David C. Whiteman, Adele C. Green, Nicholas K. Hayward, Peter G. Parsons, David M. Purdie, and Penelope M. Webb; and program no. 552429 awarded to David C. Whiteman). The Study of Digestive Health was supported by grant number 5 R01 CA 001833 from the US National Cancer Institute (awarded to David C. Whiteman). The Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS) sponsored the genotyping of oesophageal cancer and Barrett's oesophagus cases, which were used as unscreened controls in the ANZRAG cohort. BEAGESS was funded by grant R01 CA136725 from the US National Cancer Institute. Genotyping for part of the Australian twin control samples included in the ANZRAG cohort was funded by an NHMRC Medical Genomics Grant. Genotyping for the remainder of twin controls was performed by the National Institutes of Health (NIH) Center for Inherited Research (CIDR) as part of an NIH/National Eye Institute (NEI) grant 1RO1EY018246, and we are grateful to Dr Camilla Day and staff. We acknowledge with appreciation all women who participated in the QIMR Berghofer endometriosis study. We thank Endometriosis Associations for supporting study recruitment. We thank Sullivan Nicolaides and Queensland Medical Laboratory for pro bono collection and delivery of blood samples and other pathology services for assistance with blood collection. The QIMR twin and endometriosis studies were supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (241944, 339462, 389927, 389875, 389891, 389892, 389938, 443036, 442915, 442981, 496610, 496739, 552485, 552498, 1049472 and 1050208), the Cooperative Research Centre for Discovery of Genes for Common Human Diseases (CRC), Cerylid Biosciences (Melbourne), and donations from Neville and Shirley Hawkins. We thank Matthew A. Brown, Margaret J. Wright, Megan J. Campbell, Anthony Caracella, Scott Gordon, Dale R Nyholt, Anjali K Henders, B. Haddon, D. Smyth, H. Beeby, O. Zheng, B. Chapman for their input into project management, databases, sample processing, and genotyping. We are grateful to the many research assistants and interviewers for assistance with the studies contributing to the QIMR Berghofer twin collection. NEIGHBORHOOD: The NEIGHBORHOOD data collection and analysis is supported by NIH/NEI R01EY022305 (JL Wiggs) and NIH/NEI P30 EY014104 Wiggs).Support for collection of cases, controls and analysis for individual datasets is as follows.r Genotyping services for the NEIGHBOR study were provided by the Center for Inherited Disease Research (CIDR) and were supported by the National Eye Institute through grant HG005259-01 (JL Wiggs). Genotyping for the MEEI dataset and some NHS and HPFS cases (GLAUGEN) was completed at the Broad Institute and supported by GENEVA project grant HG004728 (LR Pasquale) and U01-HG004424 (Broad Institute). Genotype data cleaning and analysis for the GLAUGEN study was supported by U01HG004446 (C Laurie). Collecting and processing samples for the NEIGHBOR dataset was supported by the National Eye Institute through ARRA grants 3R01EY015872-05S1 (JL Wiggs) and 3R01EY019126-02S1 (MA Hauser). Funding for the collection of NEIGHBOR cases and controls was provided by NIH grants: EY015543 (RR Allingham), EY006827 (D Gaasterland); HL73042, HL073389, EY13315 (MA Hauser); CA87969, CA49449, UM1 CA186107, UM1 CA167552, EY009149 (PR Lichter), HG004608 (C McCarty), EY008208 (FA Medeiros), EY015473 (LR Pasquale), EY012118 (M Pericak-Vance), EY015682 (A Realini), EY011671 (JE Richards), EY09580 (JE Richards), EY013178 (JS Schuman), RR015574, EY015872 Wiggs), EY010886 (JL Wiggs), EY009847 (JL Wiggs), EY011008, EY144428 (K Zhang), EY144448 (K Zhang), EY18660 (K Zhang). The collection of Marshfield clinic cases and controls was supported by 1U02HG004608-01, 5U01HG006389-02 and NCATS/NIH grant UL1TR000427. In addition some NHS/HPFS cases and controls and analysis of GWAS data was supported by R01 CA131332. The WGHS is supported by HL043851 and HL080467 from the National Heart, Lung, and Blood Institute and CA047988 from the National Cancer Institute, the Donald W. Reynolds Foundation and the Fondation Leducq, with collaborative scientific support and funding for genotyping provided by Amgen. POAG case identification in WGHS was supported by 3R01 EY15473-5S1 (LR Pasquale). JL Wiggs and LR Pasquale are supported by the Harvard Glaucoma Center for Excellence and an unrestricted grant from Research to Prevent Blindness. Dr. Pasquale is also supported by a Harvard Medical School Distinguished Scholar award.