Journal article

Left Ventricular Dysfunction and Exercise Capacity Trajectory Implications for Subclinical Heart Failure Staging Criteria

Julian W Sacre, Chiew Wong, Yih-Kai Chan, Melinda J Carrington, Simon Stewart, Bronwyn A Kingwell



OBJECTIVES: This study aimed to determine the association of stage B heart failure (SBHF) and its constituent left ventricular (LV) abnormalities with trajectory of exercise capacity over time, and assess whether this association is modified by reversion of these LV abnormalities to normal. BACKGROUND: The LV abnormalities of SBHF may coincide with a reduction in exercise capacity that precedes the overt exercise intolerance of clinical heart failure (HF). Determining the predictive capacity of established and novel SBHF criteria for exercise capacity decline may improve HF risk stratification. METHODS: LV structure/function (echocardiography) and exercise capacity (6-min walk distance [6MWD..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by National Heart Foundation of Australia

Funding Acknowledgements

The NIL-CHF study was supported by a National Health and Medical Research Council (NHMRC) Project Grant (#472662). The study was also supported in part by the Victorian Government's Operational Infrastructure Support Program. Drs. Sacre, Stewart, and Kingwell are all supported by NHMRC Fellowships. Dr. Carrington is supported by a Future Leader Fellowship (Award Reference 100802) from the National Heart Foundation of Australia and previously throughout the duration of the NIL-CHF project, a NHMRC Fellowship. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.