Journal article

Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors

Jihyoun Jeon, Mengmeng Du, Robert E Schoen, Michael Hoffmeister, Polly A Newcomb, Sonja I Berndt, Bette Caan, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Graham G Giles, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Eric J Jacobs, Li Li, Yi Lin, Loic Le Marchand, John D Potter, Conghui Qu Show all

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2018

Grants

Awarded by National Institutes of Health


Awarded by Deutsche Forschungsgemeinschaft


Awarded by German Federal Ministry of Education and Research


Awarded by Damon Runyon Cancer Research Foundation


Awarded by NCI


Awarded by Australian National Health and Medical Research Council


Awarded by National Institutes of Health, US Department of Health and Human Services


Awarded by Canadian Institutes of Health Research


Awarded by National Cancer Institute of Canada


Awarded by National Institutes of Health, Genes, Environment and Health Initiative


Awarded by National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services


Awarded by National Cancer Institute, National Institutes of Health, US Department of Health and Human Services


Funding Acknowledgements

This work was supported by grants as follows: Hawaii Colorectal Cancer Studies 2 and 3 are supported by National Institutes of Health (R01 CA60987). The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study-II cohort. Darmkrebs: Chancen der Verhutung durch Screening: German Research Council is supported by Deutsche Forschungsgemeinschaft (BR 1704/6-1, BR 1704/6-3, BR 1704/6-4 and CH 117/1-1), and the German Federal Ministry of Education and Research (01KH0404 and 01ER0814). Diet, Activity and Lifestyle Study is supported by National Institutes of Health (R01 CA48998 to M. L. Slattery). Nurses' Health Study and Health Professionals Follow-up Study: Health Professionals Follow-up Study is supported by the National Institutes of Health (P01 CA055075, UM1 CA167552, R01 CA137178, R01 CA151993, R35 CA197735, K07 CA190673, and P50 CA127003), Nurses' Health Study is supported by the National Institutes of Health (R01 CA137178, P01 CA087969, UM1 CA186107, R01 CA151993, R35 CA197735, K07 CA190673, and P50 CA127003). Kentucky Case-Control Study was supported by the following grant support: Clinical Investigator Award from Damon Runyon Cancer Research Foundation (CI-8) and NCI R01CA136726. Melbourne Collaborative Cohort Study Axiom and OncoArray: Melbourne Collaborative Cohort Study cohort recruitment was funded by VicHealth and Cancer Council Victoria. The Melbourne Collaborative Cohort Study was further supported by Australian National Health and Medical Research Council grants 209057, 251553, and 504711 and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. Multi-Ethnic Cohort Study: National Institutes of Health (R37 CA54281, P01 CA033619, and R01 CA63464). Molecular Epidemiology of Colorectal Cancer: This work was supported by the National Institutes of Health, US Department of Health and Human Services (R01 CA81488 to SBG and GR). Newfoundland Case-Control Study: This work was supported by an Interdisciplinary Health Research Team award from the Canadian Institutes of Health Research (CRT 43821); the National Institutes of Health, US Department of Health and Human Services (U01 CA74783); and National Cancer Institute of Canada grants (18223 and 18226). The authors wish to acknowledge the contribution of Alexandre Belisle and the genotyping team of the McGill University and Genome Quebec Innovation Centre, Montreal, Canada, for genotyping the Sequenom panel in the Newfoundland Case-Control Study samples. Funding was provided to Michael O. Woods by the Canadian Cancer Society Research Institute. Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial: Intramural Research Program of the Division of Cancer Epidemiology and Genetics was supported by contracts from the Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services. Additionally, a subset of control samples were genotyped as part of the Cancer Genetic Markers of Susceptibility Prostate Cancer Genome-Wide Association Study (Yeager et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 2007; 39: 645-649), Cancer Genetic Markers of Susceptibility pancreatic cancer scan (PanScan) (Amundadottir et al.Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 2009; 41: 986-990, and Petersen et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 2010;42:224-228), and the Lung Cancer and Smoking study (Landi et al. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet 2009;85:679-691). The prostate and PanScan study datasets were accessed with appropriate approval through the dbGaP online resource (http://cgems.cancer.gov/data/) accession numbers phs000207.v1.p1 and phs000206.v3.p2, respectively, and the lung datasets were accessed from the dbGaP website (http://www.ncbi.nlm.nih.gov/gap) through accession number phs000093.v2.p2. Funding for the Lung Cancer and Smoking study was provided by National Institutes of Health, Genes, Environment and Health Initiative Z01 CP 010200, National Institutes of Health U01 HG004446, and National Institutes of Health, Genes, Environment and Health Initiative U01 HG 004438. For the lung study, the GENEVA Coordinating Center provided assistance with genotype cleaning and general study coordination, and the Johns Hopkins University Center for Inherited Disease Research conducted genotyping. Vitamins and Lifestyle study was supported by National Institutes of Health (K05 CA154337). Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. Genetics and Epidemiology of Colorectal Cancer Consortium: National Cancer Institute, National Institutes of Health, US Department of Health and Human Services (U01 CA137088; R01 CA059045; U01 CA164930).