Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity
Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton
CELL DEATH & DISEASE | NATURE PUBLISHING GROUP | Published : 2018
Glucocorticoids (GCs) are potent anti-inflammatory drugs whose mode of action is complex and still debatable. One likely cellular target of GCs are monocytes/macrophages. The role of GCs in monocyte survival is also debated. Although both granulocyte macrophage-colony stimulating factor (GM-CSF) and macrophage-CSF (M-CSF) are important regulators of macrophage lineage functions including their survival, the former is often associated with proinflammatory functions while the latter is important in lineage homeostasis. We report here that the GC, dexamethasone, induces apoptosis in GM-CSF-treated human monocytes while having no impact on M-CSF-induced monocyte survival. To understand how GCs, ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
A.A. and J.A.H. were supported in part by funding from GSK. A.D.C. and J.A.H. were supported by a grant (1043147) and J.A.H. by a Senior Principal Research Fellowship from the National Health and Medical Research Council of Australia. S.J.T. was supported by grants (5671222 and 1003131) from the National Health and Medical Research Council of Australia and by an Australian Research Council Future Fellowship.