Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age
Claire Granger, Alicia J Spittle, Jennifer Walsh, Jan Pyman, Peter J Anderson, Deanne K Thompson, Katherine J Lee, Lee Coleman, Charuta Dagia, Lex W Doyle, Jeanie Cheong
BMC PEDIATRICS | BIOMED CENTRAL LTD | Published : 2018
BACKGROUND: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. METHODS: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation). Histologic chorioamnionitis was assessed as a pre..View full abstract
Awarded by Australian National Health and Medical Research Council
Australian National Health and Medical Research Council (Project grant ID 1028822 & 1024516, Centre of Research Excellence ID 1060733, Early Career Fellowship ID 1053787 to JC, Senior Research Fellowship ID 1081288 to PA; Career Development Fellowship ID 1108714 to AS, 1085754 to DT & ID 1053609 to KJL), the Royal Children's Hospital Foundation, and the Victorian Government Operational Infrastructure Support Program.