Blood biomarkers in paediatric mild traumatic brain injury: a systematic review

Abstract

Objective: To summarize all current studies focusing on blood biomarkers in paediatric mild traumatic brain injury (mTBI) and to outline the possible use of blood biomarkers for diagnostic, prognostic and monitoring purposes within this setting. Methods: A systematic review following the PRISMA guidelines was conducted using the MEDLINE, PubMed and EMBASE databases. Results: A total of 21 studies were included in the review, encompassing a total of 14 different biomarkers. Seventeen (81%) of these studies found a significant association between biomarker concentration and mTBI characteristics, however results from studies to date are diverse and at times conflicting. Conclusion: GFAP appears..