pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions
Helen Billman-Jacobe, Yuhong Liu, Ruth Haites, Tom Weaver, Lily Robinson, Marc Marenda, Mike Dyall-Smith
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2018
Detailed annotation of an IncHI2 plasmid, pSTM6-275, from Salmonella enterica serotype 1,4,5,12:i:- strain TW-Stm6 revealed a composite structure, including antimicrobial resistance genes on mobile genetic elements. The plasmid was thermosensitive for transfer to Escherichia coli and conferred reduced susceptibility to antibiotics, copper sulfate, and silver nitrate. Metal ion susceptibility was dependent on physiological conditions, giving an insight into the environments where this trait might confer a fitness advantage.
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Awarded by NH&MRC through the Centres of Research Excellence program
This research was funded by the NH&MRC through the Centres of Research Excellence program, grant no. 1079625. Yuhong Liu received a Melbourne Research Scholarship.