Journal article

Altered functional connectivity differs in stroke survivors with impaired touch sensation following left and right hemisphere lesions

Peter Goodin, Gemma Lamp, Rishma Vidyasagar, David McArdle, Ruediger J Seitz, Leeanne M Carey

NEUROIMAGE-CLINICAL | ELSEVIER SCI LTD | Published : 2018

Abstract

One in two survivors experience impairment in touch sensation after stroke. The nature of this impairment is likely associated with changes associated with the functional somatosensory network of the brain; however few studies have examined this. In particular, the impact of lesioned hemisphere has not been investigated. We examined resting state functional connectivity in 28 stroke survivors, 14 with left hemisphere and 14 with right hemisphere lesion, and 14 healthy controls. Contra-lesional hands showed significantly decreased touch discrimination. Whole brain functional connectivity (FC) data was extracted from four seed regions, i.e. primary (S1) and secondary (S2) somatosensory cortice..

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Grants

Awarded by NHMRC


Awarded by James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award


Awarded by NHMRC Career Development Award


Awarded by Australian Research Council


Awarded by NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Injury


Funding Acknowledgements

The authors acknowledge financial support for the research from the NHMRC project grant (APP1022684: Effective sensory rehabilitation after stroke: Targeting viable brain networks); James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award (#220020413); a NHMRC Career Development Award to LMC (307905); an Australian Research Council Future Fellowship awarded to LMC (FT0992299); Perpetual Foundation, NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Injury (#1077898); Victorian Government's Operational Infrastructure Support Program.