Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery: Results from the CAPACITY and ARCADIAN studies

L Evered; B Silbert; DA Scott; H Zetterberg; K Blennow

Journal article

Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery: Results from the CAPACITY and ARCADIAN studies

L Evered, B Silbert, DA Scott, H Zetterberg, K Blennow

JAMA Neurology | AMER MEDICAL ASSOC | Published : 2018

DOI: 10.1001/jamaneurol.2017.4913

Abstract

IMPORTANCE Anesthesia and surgery are believed to act on the central nervous system by a fully reversible mechanism innocuous to nerve cells. Evidence that neurological sequelae may follow would challenge this belief and would thereby suggest a need to reassess theories of the mechanism of anesthetic action or the response of the central nervous system to surgery. OBJECTIVE To measure 2 biomarkers of neurological injury (neurofilament light and tau) in plasma in a series of timed collections before and after anesthesia and surgery. DESIGN, SETTING, AND PARTICIPANTS These 2 related observational studies (CAPACITY and ARCADIAN) recruited patients 60 years and older who were undergoing general ..

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University of Melbourne Researchers

Lis Evered Author

Brendan Silbert Author

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Grants

Awarded by Department of Health, Australian Government

Funding Acknowledgements

Drs Evered, Silbert, and Scott are supported by Department of Health National Health and Medical Research Council grant 1027178 and Australian and New Zealand College of Anaesthetists grant 15/026. Dr Evered is supported by Department of Health/National Health and Medical Research Council Dementia Research Fellowship grant 1102462. Dr Zetterberg is supported by Svenska Forskningsradet Formas (Swedish Research Council Formas) grant 2013-2546, European Research Council grant 681712, and Swedish State Support for Clinical Research grant ALFGBG-441051. Dr Blennow is supported by Swedish Alzheimer's Foundation grants AF-553101 and AF-646211, Research Council Sweden grant 14002, Swedish Brain Foundation grant FO2015-0021, and LUA/ALF-medel Vastra Gotalandsregionen grant ALFGBG-139671.